摘要
三氧化二砷(ATO)参与肝癌细胞的多种生物学过程,包括肿瘤细胞凋亡诱导、增殖抑制、侵袭转移抑制和肿瘤干细胞抑制等。ATO在肝癌治疗中有多种方式,主要包括单药治疗、联合局部治疗、联合全身治疗等。进一步研究ATO抗癌机制及临床应用有望为肝癌治疗提供新的思路。
Arsenic trioxide(ATO)is involved in a variety of biological processes of hepatocellular carcinoma(HCC)cells,including apoptosis induction,proliferation inhibition,invasion and metastasis inhibition,and tumor stem cell inhibition.ATO has a variety of therapeutic approaches in the treatment of HCC,mainly including single drug therapy,combined local therapy,combined systemic therapy,and so on.Further research on the anti-cancer mechanism and clinical application of ATO is expected to provide new ideas for the treatment of liver cancer.
作者
杜佳航
陈栋
陈耀庭
Du Jiahang;Chen Dong;Chen Yaoting(Department of Interventional Radiology,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,China)
出处
《国际肿瘤学杂志》
CAS
2021年第9期572-574,共3页
Journal of International Oncology
关键词
肝肿瘤
治疗应用
三氧化二砷
Liver neoplasms
Therapeutic uses
Arsenic trioxide