三氧化二砷抗肝癌机制及其在肝癌治疗中的研究

Research progress of arsenic trioxide in anti-liver cancer mechanism and treatment of hepatocellular carcinoma

三氧化二砷(ATO)参与肝癌细胞的多种生物学过程,包括肿瘤细胞凋亡诱导、增殖抑制、侵袭转移抑制和肿瘤干细胞抑制等。ATO在肝癌治疗中有多种方式,主要包括单药治疗、联合局部治疗、联合全身治疗等。进一步研究ATO抗癌机制及临床应用有望为肝癌治疗提供新的思路。

Arsenic trioxide(ATO)is involved in a variety of biological processes of hepatocellular carcinoma(HCC)cells,including apoptosis induction,proliferation inhibition,invasion and metastasis inhibition,and tumor stem cell inhibition.ATO has a variety of therapeutic approaches in the treatment of HCC,mainly including single drug therapy,combined local therapy,combined systemic therapy,and so on.Further research on the anti-cancer mechanism and clinical application of ATO is expected to provide new ideas for the treatment of liver cancer.