血清内皮抑素在慢性阻塞性肺病中的临床意义

Clinical significance of serum endostatin in chronic obstructive pulmonary disease

目的分析患者的血清内皮抑素(ES)在慢性阻塞性肺病(COPD)中的含量及临床意义。方法回顾性地选取2016年1月至2019年1月期间南京梅山医院COPD患者120例和健康志愿者50例,检测血清ES的含量;并进一步分析血清中ES与COPD分级、肺功能、血气分析及炎症相关标志物的相关性;同时,比较抗炎治疗前后COPD患者血清ES的变化。结果与健康对照组相比较,COPD组血清ES均明显增高(P<0.01),急性加重期COPD组血清ES明显高于稳定期COPD组(P<0.01),GOLD Ⅲ-Ⅳ级患者血清ES水平明显高于GOLD Ⅰ-Ⅱ级(P<0.01)。无论在稳定期还是急性发作期COPD患者中,血清ES水平与炎症相关指标CRP和VEGF均呈正相关(P<0.05),与肺功能指标FEV1%pre和FEV1/FVC(%)呈负相关(P<0.05)。而且,抗炎治疗后COPD患者血清ES较治疗前明显下降(P<0.05)。结论 COPD患者血清中ES水平明显增高,通过检测血清ES的水平可以预测COPD病情的严重程度。

Objective To determine the level and clinical significance of serum endostatin(ES)in chronic obstructive pulmonary disease(COPD).Methods A total of 120 COPD patients and 50 healthy volunteers in Nanjing Meishan Hospital between January 2016 and January 2019 were retrospectively enrolled and examined for serum ES levels.The correlation of serum ES with COPD grades,lung function,blood gas analysis and inflammatory markers was analyzed.The serum ES levels were also compared before and after anti-inflammatory treatment in the COPD patients.Results The serum ES level was significantly higher in COPD patients compared with healthy controls(P<0.01),in patients with acute exacerbation of COPD than in stable COPD patients(P<0.01),and in GOLD III-IV patients than in GOLDⅠ-Ⅱpatients(P<0.01).In patients with either stable COPD or acute exacerbation of COPD,the serum ES levels were positively correlated with inflammatory indicators CRP and VEGF(P<0.05),and negatively correlated with FEV_(1)% predicted FEV_(1) and FEV1/FVC(%)among other lung function indicators(P<0.05).After anti-inflammatory treatment,the serum ES level in the COPD patients was significantly lower compared with baseline(P<0.05).Conclusion The serum ES level is significantly increased in COPD patients.Determining the serum ES level may predict the severity of COPD.