地菊平肝胶囊联合辛伐他汀治疗高血压并心力衰竭的临床疗效及其对血脂、心肌重构的影响

Effect of Diju Pinggan capsule combined with simvastatin in the treatment of hypertension with heart failure patients and the impact on blood lipid and myocardial remodeling

目的探讨地菊平肝胶囊联合辛伐他汀治疗高血压并心力衰竭患者的临床疗效及其对血脂、心肌重构的影响。方法选取2019年9月—2020年9月乐安县湖坪中心卫生院收治的高血压并心力衰竭患者62例,按照随机数字表法分为对照组和观察组,各31例。对照组患者采用辛伐他汀片治疗,观察组患者在对照组基础上采用地菊平肝胶囊治疗,均持续治疗8周。比较2组患者的临床疗效及治疗前后24 h平均血压(收缩压、舒张压)、24 h血压最高值和血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、透明质酸(HA)、Ⅲ型前胶原蛋白(PCⅢP)、层粘连蛋白(LN)、N末端脑钠肽前体(NT-proBNP)水平,观察2组患者不良反应发生情况。结果观察组患者总有效率高于对照组(P<0.05)。治疗前2组患者24 h平均收缩压、舒张压及24 h收缩压、舒张压最高值比较,差异无统计学意义(P>0.05);观察组患者治疗后24 h平均收缩压、舒张压及24 h收缩压、舒张压最高值低于对照组(P<0.05)。2组患者治疗后24 h平均收缩压、舒张压及24 h收缩压、舒张压最高值均分别低于本组治疗前(P<0.05)。2组患者治疗前血清TC、TG、HDL-C、LDL-C、HA、PCⅢP、LN、NT-proBNP水平及治疗后血清TG、HDL-C水平比较,差异无统计学意义(P>0.05);观察组患者治疗后血清TC、LDL-C、HA、PCⅢP、LN、NT-proBNP低于对照组(P<0.05)。2组患者治疗后血清TC、TG、LDL-C、HA、PCⅢP、LN、NT-proBNP水平均分别低于本组治疗前,血清HDL-C水平分别高于本组治疗前(P<0.05)。2组患者治疗期间均未出现明显不良反应。结论地菊平肝胶囊联合辛伐他汀治疗高血压并心力衰竭患者的临床疗效确切,可有效改善患者心功能,调节血压、血脂水平,延缓心肌重构,且安全性较高。

Objective To observe the effect of Diju Pinggan capsule combined with simvastatin in the treatment of hypertension with heart failure patients and the impact on blood lipid and myocardial remodeling.Methods A total of 62 patients with hypertension with heart failure in Huping Central Hospital of Lean County from September 2019 to September 2020 were selected,and divided into the control group and the observation group by random number table method,31 cases in each group.Patients in the control group were given simvastatin,patients in the observation group were given Diju Pinggan capsule based on the control group,both groups were treated for 8 weeks.Clinical effect,24 h mean blood pressure(blood systolic pressure,blood diastolic pressure),maximum 24 h blood pressure and serum levels of TC,TG,HDL-C,LDL-C,HA,PC Ⅲ P,LN,NT-proBNP before and after treatment were compared between the two groups,and the incidence of adverse reactions were observed.Results Total effective rate of observation group was higher than that of control group(P<0.05).Before treatment,there was no significant difference in 24 h mean blood systolic pressure,blood diastolic pressure and maximum 24 h blood systolic pressure,blood diastolic pressure between the two groups(P>0.05);after treatment,24 h mean blood systolic pressure,blood diastolic pressure and maximum 24 h blood systolic pressure,blood diastolic pressure in the observation group were lower than those in the control group(P<0.05).In the two groups,24 h mean blood systolic pressure,blood diastolic pressure and maximum 24 h blood systolic pressure,blood diastolic pressure after treatment were lower than those before treatment,respectively(P<0.05).There was no significant difference in serum levels of TC,TG,HDL-C,LDL-C,HA,PC Ⅲ P,LN,NT-proBNP before treatment and serum levels of TG,HDL-C after treatment between the two groups(P>0.05);serum levels of TC,LDL-C,HA,PC Ⅲ P,LN,NT-proBNP in the observation group were lower than those in the control group(P<0.05).In the two groups,serum levels of TC,TG,LDL-C,HA,PC Ⅲ P,LN,NT-proBNP after treatment were lower than those before treatment,respectively(P<0.05).There was no significant adverse reactions in the two groups during treatment.Conclusion Diju Pinggan capsule combined with simvastatin have an exactly clinical effect,which can effectively improve cardiac function of patients,regulate blood pressure and blood lipid,delaying myocardial remodeling,and with high safety.