蒌芩止嗽煎治疗慢性阻塞性肺疾病急性加重期的临床疗效及其安全性

Clinical efficacy and safety of Louqin Zhisou decoction in the treatment of acute exacerbation of chronic obstructive pulmonary disease

目的探讨蒌芩止嗽煎治疗慢性阻塞性肺疾病(简称慢阻肺)急性加重期的临床疗效及其安全性。方法选取铅山县人民医院2018年3月—2020年5月收治的慢阻肺急性加重期患者80例,按照随机对照原则分为对照组40例与观察组40例。对照组予以西医药物常规治疗,观察组在对照组治疗的基础上予以蒌芩止嗽煎治疗。比较2组临床疗效,治疗前后炎性因子[白细胞计数(WBC)、C反应蛋白(CRP)、降钙素原(PCT)]、肺功能指标[第1秒用力呼气末容积(FEV_(1))、FEV_(1)占预计值百分比(FEV_(1)%)、用力肺活量(FVC)及第1秒用力呼气容积与用力肺活量比值(FEV_(1)/FVC)],观察2组不良反应发生情况。结果观察组总有效率高于对照组(P<0.05)。治疗前2组WBC、CRP、PCT比较,差异无统计学意义(P>0.05);治疗后观察组WBC、CRP、PCT低于对照组,差异有统计学意义(P<0.05)。治疗前2组FEV_(1)、FEV_(1)%、FEV_(1)/FVC比较,差异无统计学意义(P>0.05);治疗后观察组FEV_(1)、FEV_(1)%、FEV_(1)/FVC高于对照组,差异有统计学意义(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论蒌芩止嗽煎治疗慢阻肺急性加重期的临床疗效确切,可减轻炎性反应,改善肺功能,且安全性较高。

Objective To explore the clinical efficacy and safety of Louqin Zhisou decoction in the treatment of acute exacerbation of chronic obstructive pulmonary disease(referred to as COPD).Methods A total of 80 patients with acute exacerbation of chronic obstructive pulmonary disease admitted to People’s Hospital of Qianshan County from March 2018 to May 2020 were selected and divided into control group of 40 cases and an observation group of 40 cases according to the principle of randomized control.The control group was given conventional treatment with western medicine,and the observation group was given Louqin Zhisou decoction on the basis of the treatment of the control group.Clinical efficacy inflammatory factors[white blood cell count(WBC),creactive protein(CRP)and procalcitonin(PCT)],lung function index[forced endexpiratory volume in the first second(FEV_(1)),FEV_(1) Percentage of predicted value(FEV_(1)%),forced vital capacity(FVC),and maximum expiratory volume in the first second occupying forced vital capacity ratio(FEV_(1)/FVC)]before and after treatment were compared between the two groups,observe the occurrence of adverse reactions in the two groups.Results The total effective rate of the observation group was higher than that of the control group(P<0.05).Before treatment,there was no significant difference in WBC,CRP,and PCT between the two groups(P>0.05);after treatment,WBC,CRP,and PCT in the observation group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference in FEV_(1),FEV_(1)%,FEV_(1)/FVC between the two groups(P>0.05);after treatment,FEV_(1),FEV_(1)%,FEV_(1)/FVC in the observation group were higher than those in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Louqin Zhisou decoction has a definite clinical effect in the treatment of acute exacerbation of chronic obstructive pulmonary disease,inflammatory factors,improve lung function,and has high safety.