典型新型有机污染物对儿童肥胖和神经发育影响的研究进展

Effects of emerging organic contaminants on childhood obesity and neurodevelopment:A review

新型有机污染物(EOCs)是指在环境中新发现或新近引起关注的一类污染物,大多数具有持久性、生物蓄积性以及内分泌干扰性,可以通过呼吸道、消化道及皮肤接触等方式进入人体。大多数EOCs可以通过胎盘和血脑屏障,并通过激素扰乱等方式影响子代的生长及神经发育;生命早期是特殊的发育阶段,子代更易受到EOCs的影响。本文旨在对常见的EOCs如多溴联苯醚、多氯联苯、双酚A、全氟及多氟烷基化合物对子代肥胖以及不良神经发育的流行病学研究结果进行综述。研究EOCs的健康效应,改进EOCs暴露评估,识别易感人群和敏感窗口期,有助于阐明生命早期EOCs暴露对子代肥胖和神经发育的影响,为公共卫生的干预提供科学依据。

Emerging organic contaminants(EOCs) are new or existing chemicals that their human risks are of concern. Most EOCs are persistent, bioaccumulative, and endocrine disrupting. Humans can be exposed to EOCs through inhalation, ingestion, dermal contact, ect. Most EOCs could pass through the placenta and blood-brain barrier and exert adverse health effects by interfering hormones. Offspring in early-life are susceptible to EOCs due to their special developmental stage. Herein, exposure to several ubiquitous EOCs such as polybrominated diphenyl ethers(PBDEs), polychlorinated biphenyls(PCBs), bisphenol A(BPA), and poly-and perfluoroalkyl substances(PFASs) in early life and their relationships with obesity or neurodevelopment were summarized. Quantifying the health effects of EOCs mixtures, improving EOCs exposure assessment, and identifying susceptible populations and sensitive windows could help establish the causal effects of EOCs exposure in early life on childhood obesity and neurodevelopment and and provide a scientific basis for public interventions.