替格瑞洛联合阿司匹林在急性冠脉综合征治疗中的应用效果

The Effect of Ticagrelor Combined with Aspirin in the Treatment of Acute Coronary Syndrome

目的:探讨替格瑞洛联合阿司匹林在急性冠脉综合征治疗的应用效果。方法:选取2019年9月—2020年9月该院收治的76例急性冠脉综合征患者作为研究对象,通过随机数字表法分为观察组与对照组,每组38例。两组患者均接受介入手术治疗,对照组给予阿司匹林联合氯吡格雷治疗,观察组给予阿司匹林联合替格瑞洛治疗,比较两组临床治疗疗效、心功能、血清指标、血小板计数、血小板聚集率及不良心血管事件发生率。结果:观察组总有效率为97.4%,高于对照组的81.6%(P<0.05)。观察组LVEF、LVESd、LVEDd优于对照组(P<0.05);观察组BNP、cTnI低于对照组(P<0.05);观察组血小板计数、血小板聚集率低于对照组(P<0.05);观察组不良心血管事件发生率低于对照组(P<0.05)。结论:应用替格瑞洛联合阿司匹林治疗急性冠脉综合征效果显著,可有效改善患者心功能,加快机体各功能恢复正常,且不良反应少。

Objective:To explore the effect of ticagrelor combined with aspirin in the treatment of acute coronary syndrome.Methods:A total of 76 patients with acute coronary syndrome admitted to the hospital from September 2019 to September 2020 were selected as the research objects,and they were divided into observation group and control group by random number table method,with 38 cases in each group.Both groups of patients received interventional surgery,while the control group was treated with aspirin combined with clopidogrel,and the observation group was treated with aspirin combined with ticagrelor.The clinical therapeutic effects,cardiac function,serum indexes,platelet count,platelet aggregation rate and platelet aggregation rate and the incidence of adverse cardiovascular events were compared between the two groups.Results:The total effective rate of the observation group was 97.4%,which was higher than 81.6%of the control group(P<0.05).The level of LVEF,LVESd,and LVEDd in the observation group were better than those in the control group(P<0.05);the level of BNP and cTnI in the observation group were lower than those in the control group(P<0.05);the platelet count and platelet aggregation rate in the observation group were lower than those in the control group(P<0.05);the incidence of adverse cardiovascular events in the observation group was lower than that in the control group(P<0.05).Conclusion:The application of ticagrelor combined with aspirin in the treatment of acute coronary syndrome has a signifi cant effect,which can effectively improve the heart function of patients,accelerate the recovery of various functions of the body,and have fewer adverse reactions.