甘露醇治疗脑水肿的剂量与不良反应分析

Analysis of the Dose and Adverse Reaction of Mannitol in the Treatment of Cerebral Edema

目的:探讨不同剂量甘露醇治疗脑水肿的效果,分析出现的不良反应。方法:连续纳入2019年2月—2021年2月在该院接受脑水肿治疗的患者200例,按照随机数表法分为试验组和对照组,各100例。对照组采用常规治疗联合20%甘露醇250 ml脱水治疗,试验组采用常规治疗联合20%甘露醇125 ml脱水治疗,比较两组治疗效果、脑血肿体积变化、治疗前后生活质量评分、治疗前后美国国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)、吞咽障碍筛查量表(Burke)评分、不良反应发生率。结果:治疗后,试验组总有效率高于对照组(P<0.05);试验组脑血肿体积小于对照组,生活质量评分、NIHSS评分、Burke评分优于对照组(P<0.05);试验组不良反应发生率低于对照组(P<0.05)。结论:小剂量甘露醇治疗效果显著,可以改善患者的生活质量和神经功能,且不良反应较小,安全性较高。

Objective:To explore the effects of different doses of mannitol in the treatment of cerebral edema,and analyze the adverse reactions.Methods:A total of 200 consecutive patients who were treated for cerebral edema in the hospital from February 2019 to February 2021 were continuously included.According to the random number table method,they were divided into the test group and the control group,with 100 cases in each group.The control group was treated with conventional treatment combined with 20%mannitol 250 ml dehydration treatment,and the test group was treated with conventional treatment combined with 20%mannitol 125 ml dehydration treatment.The treatment effect,cerebral hematoma volume change,quality of life score before and after treatment,National Institutes of Health Stroke Scale(NIHSS),Swallowing Disorder Screening Scale(Burke)score before and after treatment,incidence of adverse reactions were compared between the two groups.Results:After treatment,the total effective rate of the test group was higher than that of the control group(P<0.05);the volume of cerebral hematoma in the test group was smaller than that of the control group,the quality of life score,the NIHSS and Burke scores of the test group were better than the control group(P<0.05);the incidence of adverse reactions in the test group was lower than that in the control group(P<0.05).Conclusion:Low-dose mannitol has a signifi cant therapeutic effect,can improve the quality of life and nerve function of patients,and has less adverse reactions and high safety.It is worthy of clinical widespread promotion.