补肾解郁汤治疗肾虚肝郁型更年期综合征临床研究

Clinical Study on Bushen Jieyu Tang for Climacteric Syndrome of Kidney Deficiency and Liver Depression Type

目的:观察补肾解郁汤治疗肾虚肝郁型更年期综合征的临床效果。方法:选取肾虚肝郁型更年期综合征患者98例,按随机数字表法分成对照组及观察组各49例。对照组采用更年安片治疗,观察组采用补肾解郁汤治疗。治疗12周后,观察比较2组不同治疗时间点改良Kupperman评分;并对2组治疗前后血清生殖内分泌激素、血脂水平进行分析。结果:治疗前,2组改良Kupperman评分比较,差异无统计学意义(P>0.05);治疗1周、4周、12周,2组改良Kupperman评分呈下降趋势,与治疗前比较,差异均有统计学意义(P<0.05),且观察组改良Kupperman评分低于对照组(P<0.05)。治疗前,2组血清雌二醇(E2)、促黄体生成素(LH)、促卵泡刺激素(FSH)水平比较,差异无统计学意义(P>0.05)。治疗后,2组E2水平均较治疗前升高(P<0.05),LH、FSH水平较治疗前降低(P<0.05);且观察组上述指标改善较对照组更显著(P<0.05)。治疗前,2组低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)、总胆固醇(TC)水平比较,差异无统计学意义(P>0.05)。治疗后,2组LDL-C、TG、TC水平均较治疗前降低(P<0.05),HDL-C水平均较治疗前升高(P<0.05);且观察组上述指标改善较对照组更显著(P<0.05)。结论:补肾解郁汤治疗肾虚肝郁型更年期综合征效果显著,可有效缓解患者更年期症状,改善血清性激素水平及血脂水平。

Objective:To observe the clinical effect of Bushen Jieyu tang for climacteric syndrome of kidney deficiency and liver depression type.Methods:A total of 98 cases of patients with climacteric syndrome of kidney deficiency and liver depression type were selected and divided into the control group and the observation group according to the random number table method,49 cases in each group.The control group was treated with Gengnian’an pills,and the observation group was treated with Bushen Jieyu tang.After 12-week treatment,scores of modified Kupperman scale at different time points of treatment were observed and compared between the two groups;levels of reproductive endocrine hormone and blood lipid in serum in the two groups were analyzed before and after treatment.Results:Before treatment,there was no significant difference being found in the comparison of modified Kupperman scores between the two groups(P>0.05).When compared with those before treatment,the modified Kupperman scores in the two groups showed a downward trend after one week,four weeks and twelve weeks of treatment,differences being significant(P<0.05);the modified Kupperman score in the observation group was lower than that in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of E2,LH,and FSH between the two groups(P>0.05).After treatment,levels of E2 in the two groups were increased when compared with those before treatment(P<0.05),and levels of LH and FSH were decreased(P<0.05);the improvement of the three indexes above in the observation group was more significant than that in the control group(P<0.05).Before treatment,when compared levels of LDL-C,HDL-C,TG,and TC between the two groups,there was no significance being found in the difference(P>0.05).After treatment,levels of LDL-C,TG,and TC in the two groups were decreased when compared with those before treatment(P<0.05),and HDL-C level in the two groups were increased(P<0.05);the improvement of the four indexes above in the observation group was more significant than that in the control group(P<0.05).Conclusion:Bushen Jiuyu tang has a significant effect in the treatment of climacteric syndrome of kidney deficiency and liver depression type.It can effectively relieve symptoms of menopause,improve levels of sex hormones in serum and blood lipid.