单克隆B淋巴细胞增多症

Monoclonal B-cell lymphocytosis

单克隆B淋巴细胞增多症(monoclonal B-cell lymphocytosis, MBL)是指健康个体外周血存在低水平的单克隆B淋巴细胞。自90年代初MBL在人群中首次发现,距今近30年的时间里,针对MBL的生物学机制的研究已取得了阶段性进展。MBL是一个存在高度异质性的庞大群体,但迄今为止,针对MBL人群的管理尚无明确的国际共识和指南可循。本文就MBL的诊断及分型、流行病学特点、分子遗传学机制及该人群的管理进行综述。

Monoclonal B-cell lymphocytosis(MBL)is defined as the presence of a low level of clonal B-cell in the peripheral blood of healthy individuals.Since the first discovery of MBL in the early 1990 s,great progress has been made in the understanding of the biological mechanism of MBL in the past 30 years.The population of MBL is large and heterogeneous.However,there is no consensus or guidelines for the management of MBL so far.This article reviews the epidemiology,diagnosis,classification,molecular genetics,and management of MBL.