抗-M抗体致噬血细胞综合征患者迟发性溶血性输血反应1例

Delayed hemolytic transfusion reaction in a patient with hemophagocytic syndrome induced by anti-M antibody

1病例介绍患者,男,58岁,黄疸高热20余天,三系减低,胆红素升高、转氨酶升高,铁蛋白>1500 ng/mL,腹部B超提示肝脾肿大,诊断为噬血细胞综合征。因贫血申请输注红细胞治疗,输血前相容性检测结果见表1,血型B型Rh阳性,不规则抗体筛查(微柱凝胶法)阴性,与随机献血员的红细胞交叉配血(微柱凝胶法)相合。2试剂与仪器凝聚胺(BASO,批号:A190702);BIORAD离心机和孵育器.

A 58 years old man was diagnosed with hemophagocytic syndrome.He received blood transfusion for anemia.After transfusion,erythrocyte transfusion was ineffective and bilirubin increased.The direct antibody test(DAT)was more strongly positive than before.The irregular antibody was screened as positive by salt water test tube,and the test result of red blood cell exudate was consistent with that of irregular antibody.It was identified as anti-M antibody by spectrum cell,which could be diagnosed as delayed hemolytic transfusion reaction caused by anti-M antibody.