聚己内酯药物控释载体结构及制备方法研究进展

Research Progress of Structure and Fabrication Process of the Polycaprolactone Controlled Drug Release System

聚己内酯作为一种无毒且分子量可控的合成高分子材料,由于自身具有良好的生物相容性、不同高聚物相容性以及生物降解性等优势被广泛应用于生物医疗、工业及生活日用等领域中,是一种非常有前景的高分子材料。随着精准医疗理念及现代制造技术的不断融合发展,聚己内酯被制造成多种结构用于实现药物的控制释放,以提高药物在疾病治疗中的有效性及降低其副作用。本文综述了国内外关于聚己内酯在多种制备工艺的基础上被制备为微球、纤维、胶束及水凝胶药物载体的研究进展,分析了不同载体制备工艺的优缺点,展望了聚己内酯作为药物载体材料未来的发展方向,旨在为聚己内酯药物控释载体研究提供一定的参考。

Polycaprolactone is a nontoxic and controllable synthesis of the molecular weight of polymer materials,while has good biocompatibility,different polymer compatibility and biodegradability advantages.Therefore,polycaprolactone is widely used in biomedical,industrial and daily life.With the continuous development of precision medicine concept and modern manufacturing technology,polycaprolactone is manufactured into a variety of structures to achieve controlled drug release,in order to improve the effectiveness of drugs in disease treatment and reduce its side effects.In this study,the research progress of polycaprolactone on microspheres,fibers,micelles and hydrogels drug carriers are reviewed based on the preparation technology,the advantages and disadvantages of different carrier preparation methods have been analyzed,and the future development direction of polycaprolactone as drug carrier material is prospected.The purpose of this study is to provide some references for the research of polycaprolactone controlled release carriers.