摘要
自然杀伤细胞2族成员D(natural killer group 2 member D,NKG2D)是由NK细胞表达的一种免疫受体,可识别靶细胞表面上的人类主要组织相容性复合体Ⅰ类多肽相关序列(major histocompatibility complex Class I polypetide-related chain,MIC)A/B。NKG2D与MICA/B的相互作用,在病毒感染和癌症的免疫监视中发挥重要作用。该文通过膜结合型MICB下调、分泌型MICB增多及MICB基因多态性三部分对MICB/NKG2D信号通路在免疫逃逸中的研究进展进行综述。
Natural killer group 2 member D(NKG2D)is an immune receptor expressed by NK cells that recognizes the human major histocompatibility complex class I polypetide-related chain(MIC)A/B on the cell surface.The interaction between NKG2D and MICA/B plays an important role in the immunosurveillance of viruses infection and cancers.In this article,we review the research progress of the MICB/NKG2D signaling pathway in immune escape including three parts:down-regulation of membrane-bound MICB,increase of secretory MICB,and polymorphism of MICB genes.
作者
魏昂(综述)
王天有
张蕊
李志刚(审校)
Wei Ang;Wang Tianyou;Zhang Rui;Li Zhigang(Hematology Center,Beijing Key Laboratory of Pediatric Hematology Oncology National Key Discipline of Pediatrics(Capital Medical University)Key Laboratory of Major Disease in Children,Ministry of Education Beijing Children′s Hospital,Capital Medical University,National Center for Children′s Health,Beijing 100045,China;Hematologic Disease Laboratory,Hematology Center,Beijing Key Laboratory of Pediatric Hematology Oncology National Key Discipline of Pediatrics(Capital Medical University)Key Laboratory of Major Diseases in Children,Ministry of Education Beijing Pediatric Research Institute,Beijing Children′s Hospital,Capital Medical University,National Center for Children′s Health,Beijing 100045,China)
出处
《国际儿科学杂志》
2021年第9期584-588,共5页
International Journal of Pediatrics
基金
国家科技重大专项(2017ZX09304029001)
北京市自然科学基金(7214226)
北京市教育委员会科技发展计划一般项目(KM202110025011)。
