摘要
哮喘是儿童常见的慢性气道炎症性疾病。近几十年,全球儿童哮喘患病率呈显著上升趋势。作为一种异质性疾病,哮喘存在多种表型,在儿童以2型(嗜酸粒细胞性)气道炎症为主。呼出气一氧化氮(fractional exhaled nitric oxide,FeNO)是目前国际公认的嗜酸粒细胞性气道炎症标志物,其在儿童哮喘诊治中的价值逐渐得到认可。该文就FeNO的来源、检测方法、可能影响因素及其在儿童哮喘诊治中的作用作一综述。
Asthma is a common chronic airway inflammatory disease in children.In recent decades,the global prevalence of asthma in children has been increasing significantly.As a heterogeneous disease,asthma presents multiple phenotypes,with the type 2(eosinophilic)airway inflammation predominating in children.Currently,fractional exhaled nitric oxide(FeNO)is an internationally recognized marker of eosinophilic airway inflammation,and its value in the diagnosis and treatment of asthma in children has been gradually recognized.This article reviews the sources,detection methods,possible influencing factors of FeNO and its role in the diagnosis and treatment of asthma in children.
作者
王梦娟
刘长山
Wang Mengjuan;Liu Changshan(Department of Paediatrics,The Second Hospital of Tianjin Medical University Children′s Respiratory and Asthma Research Center of Tianjin Medical University,Tianjin 300211,China)
出处
《国际儿科学杂志》
2021年第9期599-604,共6页
International Journal of Pediatrics
基金
天津市卫生行业重点攻关项目(16KG116)。
关键词
呼出气一氧化氮
气道炎症
儿童哮喘
Exhaled nitric oxide
Airway inflammation
Asthma in children
