多组学技术在职业性噪声听力损失易感性研究中的应用及展望

Application and prospect of multiomics techniques in susceptibility to occupational noise hearing loss

随着技术的不断革新,基因组学及其他组学技术,如转录组学、蛋白质组学、代谢组学,日益成为精准医疗的重要基础。目前职业性噪声听力损失(ONHL)易感性的研究多集中于基因组学,而构建精准医疗的未来是当前ONHL研究领域的重点。相比于单一组学的研究,利用多组学分析可以综合地提供ONHL易感性的信息流。本文概述了不同组学技术的优势和局限性以及各个组学在疾病中的应用,并重点分析了多组学技术在ONHL易感性研究中应用的可行性。通过多组学技术分析,可以更好地引导临床研究对疾病的全面认识。

With the continuous innovation of technology,genomics and other omics techniques,such as transcriptomics,proteomics,and metabolomics,are increasingly becoming an important basis for precision medicine.Current research on susceptibility to occupational noise hearing loss(ONHL)has focused on genomics.Building the future of precision medicine is the focus of current ONHL research.Compared to single-omics studies,the use of multi-omics analysis can provide an integrated flow of information on ONHL susceptibility.This paper outlines the advantages and limitations of different histological techniques and the application of each histology in the disease,and focuses on the feasibility of applying multi-omics techniques in ONHL susceptibility research.The analysis of multi-omics techniques can better guide the comprehensive understanding of the disease in clinical research.