针刺眼周穴联合新明Ⅰ穴治疗干眼的临床疗效观察

Clinical efficacy observation of acupuncture at peri-ocular acupoints combined with Xinming Ⅰ in treating dry eye

目的:观察针刺眼周穴联合新明Ⅰ穴治疗干眼的临床疗效及安全性。方法:将60例干眼患者随机分为对照组和试验组,每组30例,对照组右旋糖酐羟丙甲纤维素滴眼液滴眼,每天3次,每次1滴,治疗4周。试验组针刺双侧眼周穴(太阳、睛明、攒竹、丝竹空、瞳子髎)联合新明Ⅰ穴,隔日1次,每周3次,治疗4周,共12次。观察两组治疗前后干眼症状积分、视觉模拟评分(VAS)、泪液分泌量试验(SⅠT)、泪膜破裂时间(BUT)、角膜荧光素染色(CFS)以及临床疗效的差异,并记录不良反应。结果:治疗前后比较,两组干眼症状积分及CFS评分显著降低(P<0.05,P<0.01),SⅠT值及BUT显著升高(P<0.01);试验组VAS评分显著降低(P<0.01)。试验组较对照组在干眼症状积分、VAS、SⅠT值及BUT方面显著改善(P<0.05,P<0.01)。试验组总有效率[82.8%(24/29)]高于对照组[67.9%(19/28)](P<0.05)。结论:针刺眼周穴联合新明Ⅰ穴在改善干眼患者眼部疼痛不适等临床症状、促进泪液分泌、延长BUT方面优于右旋糖酐羟丙甲纤维素滴眼液,且无明显不良反应。

Objective: To observe clinical therapeutic effect and safety on dry eye(DE) of acupuncture at peri-ocular acupoints and Xinming Ⅰ. Methods: A total of 60 patients with DE were randomized into a control group and an experimental group, 30 cases in each one. In the control group, Beiran eye drops were administered, one drop each time, 3 times a day for 4 weeks;In the experimental group, acupuncture was applied at Xinming Ⅰ and peri-ocular acupoints which included Jingming(BL 1), Cuanzhu(BL 2), Taiyang(EX-HN 5), Sizhukong(TE 23), Tongziliao(GB 1), once every other day, 3 times a week for 4 weeks, a total of 12. Then, the total scores of dry eye symptom, visual analogue scale(VAS), tear break-up time(BUT), Schirmer Ⅰ test(SⅠT), cornea fluorescein staining(CFS), and the clinical efficacy differences were observed before and after the treatment and the side-effects were recorded in the 2 groups. Results: Compared before treatment, after treatment, the total scores of dry eye symptom and CFS in two groups were significantly decreased(P<0.05, P<0.01), BUT and SⅠT value in two groups were significantly increased after treatment(P<0.01);the VAS score in the experimental group obviously declined(P<0.01). Compared between the two groups after treatment, the improvement in the integral of dry eye symptom, VAS, BUT and SⅠT value in the experimental group was superior to the control group, the difference was statistically significant(P<0.05, P<0.01). Besides, the total effective rate in the experimental group [82.8%(24/29)] was higher than the control group [67.9%(19/28)], the difference was statistically significant(P<0.05). Conclusion: Acupuncture at peri-ocular acupoints and Xinming Ⅰ is superior to Beiran eye drops in the treatment of DE in relief the clinical symptoms such as ocular pain, prolonging tear break-up time, and promoting secretion of tears. There are no obvious adverse events in acupuncture in DE.