PD-1/PD-L1在自身免疫性疾病中作用的研究进展

Research Progress of PD-1/PD-L1 in Autoimmune System Disease

程序性死亡受体-1(programmedcelldeathreceptor1,PD-1)及其配体(programmeddeathligand1,PD-L1)在抑制T细胞信号转导,介导机体免疫耐受和维持免疫稳态中起着重要作用。在多种自身免疫性疾病的发生发展中均可出现PD-1/PD-L1的功能异常。了解PD-1/PD-L1在自身免疫性疾病中的作用机制,通过调节PD-1/PD-L1来治疗多种免疫相关疾病,改善患病人群生活质量,具有重要现实意义。该文对PD-1/PD-L1在多种自身免疫系统疾病中作用的最新研究进展作一综述。

Programmed death receptor 1(PD-1)and its ligand(PD-L1)play an important role in inhibiting T cell signaling,mediating immune tolerance and maintaining immune homeostasis.Disfunction of PD-1/PD-L1 can occur in the occurrence and development of various autoimmune diseases.It is of great practical significance to understand the action mechanism of PD-1/PD-L1 in autoimmune system diseases,and to adjust PD-1/PD-L1 to treat various immune-related diseases and improve the quality of life of patients.In this review,we will make a comprehensive introduction of PD-1/PD-L1 in various autoimmune diseases from the latest research.