复合还原剂硼氢化钠/三氯化铁对亚砜的还原

Reduction of Sulfoxides with Combined Reducing Agent Ferric Chloride/Sodium Borohydride

硼氢化钠是一种温和、高选择性的亲核还原剂。一般它只能还原醛、酮和酰氯,而对其它功能团不起作用。因而其应用范围有一定的限制。据文献报道,某些金属卤化物能有效地提高硼氢化钠的还原性能。复合还原剂硼氢化钠/三氯化铁已应用于将β-二烷基氨基共轭烯酮还原为相应的饱和γ-氨基醇。本文研究了硼氢化钠/三氯化铁对亚砜的还原反应。

Under mild conditions various sulfoxides were reduced to sulfides by combined reducing agent ferric chloride/sodium borohydride in excellent yields. The reduction mechanism was also discussed.