摘要
烃氧基丙二酸酯在有机合成中是有用的试剂,一般来讲,实验室的四类制备方法都有不足之处:(1)烃氧基乙酸酯与草酸酯或碳酸酯之间的酯缩合反应。此法虽使用最广,但使用草酸酯的方法中,脱羰反应往往不完全,并且烦琐,而使用碳酸酯,因其反应性较差,也常影响制备的结果。
Alkoxymalonic esters are useful reagents in organic syntheses, but most, of the methods for their preparation found in the literatures[1-7] are of restricted applications, and in some of these methods the yields are unsatisfactory, the starting materials are not readily available, or the procedures for preparation are somewhat tedious. In order to improve such a situation, a general applicable new method with a good yield (mostly over 75%) has been proposed. The reaction is carried out with an alcohol ROH (or a phenol) and an alkyl (R’) bromomalonate in the presence of triethylamine where R’ should be equal to R for preventing transesterification and mixed alkoxylation. But ethyl bromomalonate is quite feasible in the preparation of phenoxymalonate because transesterification product has not been isolated.
作者
王川
李季
叶秀林
Wang Chuan;Li Ji;Ye Xiulin(Department of Chemistry,Peking University,Beijing)
出处
《高等学校化学学报》
SCIE
EI
CAS
1988年第12期1299-1301,共3页
Chemical Journal of Chinese Universities
关键词
烃氧基丙二酸酯
溴代丙二酸酯
三乙胺
制备
Alkoxymalonic esters
Bromomalonic esters
Triethylamine
Preparation