简单芳香族醛、酮化合物相转移催化Kishner-Wolff反应

Kishner-Wolff Reaction Using Phase Transfer Catalyst for Simple Aromatic Carbonyl Compounds

Kishner-wolff反应(简称K-W反应)是1911—1912年发现的,它是还原醛和酮的腙或缩氨脲为烃的著名方法。黄鸣龙、Cram、Grundon等人曾研究过此反应。1979年,我们用冠醚作相转移催化剂实现了相转移催化K-W反应。 本文探讨了相转移催化K-W反应的适用范围。研究了八个芳香族醛、酮化合物的还原,其结果列于表1。

The limitation of application of Kishner-Wolff reaction using phase transfer catalyst was studied. Eight aromatic carbonyl compounds i. e., benzophenone, fluo-renone,acetophenone, benzaldehyde, p-amino-benzaldehyde, p-methoxybenzaldehyde, o-chlorobenzaldehyde, p -nitrobenzaldehyde were investigated.