一种新的马钱子碱液膜电极的研制与应用

PREPARATION AND APPLICATION OF A NEW STRYCHNINE-SELECTIVE LIQUID MEMBRANE ELECTRODE

本文以四间甲苯硼酸根用作新阴离子缔合剂,并以与马钱子碱形成的离子缔合物作活性物质,代替文献中的苦酮酸-马钱子碱装制电极。电极对马钱子碱响应的线性范围为1×10^(-2)—5×10^(-6)M,检测下限可达1×10^(-6)M,对毛果云香碱、阿托品和辛可宁等生物碱的选择性系数及响应时间等性能,均比文献报导为佳。

A new strychnine-selective liquid membrane electrode made with strychnine-tetra(m-methylphenyl)borate ion-pair complex is developed.The electrode shows Nernstian response down to 5×10^(-6)M strychnine solutions with a slope of 56mV/concentration decade,and better selectivity than previously published one.Rapid and accurate methods for direct potentiometry or potentiometric titration of strychnine in pharmaceutical preparations are suggested.