通体结香技术产沉香的药效学研究进展及药用开发前景

Pharmacodynamics research progress and medicinal development prospect of Agar-Wit agarwood

沉香为名贵南药,作为中医临床常用理气药,记载有"行气止痛、温中止呕、纳气平喘"的功效。现代药效学研究显示,沉香有镇静、镇痛、抗菌、抗炎、抗肿瘤等较广泛的药理活性。前期受资源限制,其药理学研究相对薄弱。课题组对"通体结香技术"的突破,解决了药材来源的瓶颈问题,并开展了系统的药效学研究。针对本课题组已证实的通体沉香的药效进行概述,并比较通体沉香与传统沉香药效作用的异同,为更好地指导通体沉香替代传统沉香在中医药临床应用、深入通体沉香的研究及产品开发提供参考。

As a famous southern medicine,agarwood is commonly used in the clinical practice of traditional Chinese medicine for regulating Qi. Studies on pharmacodynamics show that agarwood has a wide range of pharmacological activities,such as sedation,analgesia,antibacterial,anti-inflammatory and anti-tumor. Owing to the restriction of wild resources,the pharmacological research on agarwood is still relatively weak. With the breakthrough of“whole-tree agarwood-inducing technique”(Agar-Wit),our research team has solved the bottleneck problem of medicinal material sources,and carried out a systematic pharmacodynamic study. In this paper,the pharmacodynamic effects of Agar-Wit agarwood confirmed by our research team are summarized,and the similarities and differences between the pharmacodynamic effects of Agar-Wit agarwood and traditional agarwood are compared,so as to provide reference for better guiding the application of Agar-Wit agarwood in replacing traditional agarwood in traditional Chinese medicine clinical practice,in-depth research on Agar-Wit agarwood and product development.