摘要
沉香为名贵南药,作为中医临床常用理气药,记载有"行气止痛、温中止呕、纳气平喘"的功效。现代药效学研究显示,沉香有镇静、镇痛、抗菌、抗炎、抗肿瘤等较广泛的药理活性。前期受资源限制,其药理学研究相对薄弱。课题组对"通体结香技术"的突破,解决了药材来源的瓶颈问题,并开展了系统的药效学研究。针对本课题组已证实的通体沉香的药效进行概述,并比较通体沉香与传统沉香药效作用的异同,为更好地指导通体沉香替代传统沉香在中医药临床应用、深入通体沉香的研究及产品开发提供参考。
As a famous southern medicine,agarwood is commonly used in the clinical practice of traditional Chinese medicine for regulating Qi. Studies on pharmacodynamics show that agarwood has a wide range of pharmacological activities,such as sedation,analgesia,antibacterial,anti-inflammatory and anti-tumor. Owing to the restriction of wild resources,the pharmacological research on agarwood is still relatively weak. With the breakthrough of“whole-tree agarwood-inducing technique”(Agar-Wit),our research team has solved the bottleneck problem of medicinal material sources,and carried out a systematic pharmacodynamic study. In this paper,the pharmacodynamic effects of Agar-Wit agarwood confirmed by our research team are summarized,and the similarities and differences between the pharmacodynamic effects of Agar-Wit agarwood and traditional agarwood are compared,so as to provide reference for better guiding the application of Agar-Wit agarwood in replacing traditional agarwood in traditional Chinese medicine clinical practice,in-depth research on Agar-Wit agarwood and product development.
作者
王灿红
王帅
刘洋洋
杨云
郭鹏
魏建和
WANG Canhong;WANG Shuai;LIU Yangyang;YANG Yun;GUO Peng;WEI Jianhe(Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine&Key Laboratory of State Administration of Traditional Chinese Medicine for Agarwood Sustainable Utilization,Hainan Branch Institute of Medicinal Plant,Chinese Academy of Medical Sciences,Haikou 570311,Hainan,China;Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine,National Engineering Laboratory for Breeding of Endangered Medicinal Materials,Institute of Medicinal Plant Development,Chinese Academy of Medical Science,Beijing 100193,China)
出处
《生物资源》
CAS
2021年第4期328-335,共8页
Biotic Resources
基金
国家重点研发计划项目(2018YFC1706400)
中国医学科学院医学与健康科技创新工程项目(2016-I2M-2-003)
中组部“万人计划”(99950534)
海南省自然科学基金创新团队项目(2017CXTD022)。
关键词
通体沉香
药理作用
作用机制
Agar-Wit agarwood
pharmacological effect
mechanism of action