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潍坊地区血小板输注无效患者抗体鉴定与分析

Identification and analysis of platelet antiboies in the pations with platelet transfusion refractoriness in Weifang area
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摘要 目的:初步探讨潍坊地区发生血小板输注无效患者的血小板抗体类型。方法:排除非免疫因素,采用PAKPLUS试剂盒对2012年8月~2013年2月的89例发生血小板输注无效的患者进行血小板相关抗体的鉴定,分析HLA-I类抗体与HPA抗体的分布情况,评价抗体阳性患者进行配合性血小板输注后的效果。结果:89例患者中,81例检测出HLA-Ⅰ类抗体和(或)HPA抗体,其中只有HLA-Ⅰ类抗体阳性48例(53.94%),只有HPA抗体阳性22例(24.72%),两类抗体均呈现阳性11例(12.36%);均未检出两类抗体8例(8.99%);对33例HPA抗体阳性患者中,GPⅡb/Ⅲa抗体共29例(35.80%),GPIa/Ⅱa抗体共21例(25.93%),GPIb/Ⅸ抗体共7例(8.64%),GP IV抗体共4例(4.94%);HLA-Ⅰ类抗体或HPA阳性抗体患者中女性为47例,男性为34例,差异有统计学意义;81例抗体阳性患者经输注配合性血小板后均为有效性输注。结论:潍坊地区血小板输注无效患者中主要为HLA-I类抗体,阳性抗体在女性群体中所占比例要高于男性群体,抗体阳性患者经输注配合性血小板后均为有效性输注。 Objective:To investigate the type of platelet antibody with platelet transfusion refractoriness(PTR)in Weifang area.Methods:During August 2012 to February 2013,Eliminating the non-immune factors,89 cases of PTR patients were detected for platelet associated antibodies,then analyzed the distributions of HLA-Ⅰ or HPA antibody and evaluated the effect of synergistic platelet infusion in the positive patients.Results:Among the 89 cases,81 cases were found with HLA-Ⅰ and(or)HPA antibody positive,among them,48 cases(53.94%)were anti-HLA-Ⅰ positive,22 cases(24.72%)were anti-HPA positive,11 cases(12.36%)contained two kinds of antibody;neither of them in 8 cases(8.99%).Among the 33 cases of anti-HPA positive pations,the anti-GPⅠb/Ha were 29 cases(35.80%),anti-GPⅠa/Ⅰa were 21 cases(25.93%),anti-GPⅠb/Ⅸ were 7 cases(8.64%),and-GPⅣ were 4 cases(4.94%).The antibody positive rate in female patients was higher than that in male,and there had statistical significance,All 81 patients with posive antibody achieved remarkable results with platelet transfusion appropriately.Conclusion:In the PTR patients,platelet associated antibody was mainly anti-HLA-Ⅰ,antibody positive rnate of the female was higher than the male,the positive antibody patients improved significantly with platelet transfiusion appropriately.
作者 孙福廷 王立萍 姜坤 韩海峰 赵月凯 吴晓春 SUN Fu-ting;WANG Li-ping;JIANG Kun(Department of Blood Transfusion,Weifang People's Hospital,Shandong Weifang 261041)
出处 《医学检验与临床》 2021年第9期38-41,共4页 Medical Laboratory Science and Clinics
关键词 血小板输注无效 HLA-Ⅰ类抗体 HPA抗体 Platelet transfusion refractory(PTR) HLA-Ⅰantibody HPA antibody
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