碳酸镁铝与奥美拉唑治疗胃溃疡并胃出血的效果与安全性评价

Evaluation of the efficacy and safety of magnesium aluminum carbonate and omeprazole in the treatment of gastric ulcer and gastric bleeding

目的:探讨碳酸镁铝和奥美拉唑联合治疗胃溃疡合并胃出血的临床效果和安全性。方法:2018年11月-2020年1月收治胃溃疡合并胃出血患者75例,数字双盲法分为两组。对照组单独给予奥美拉唑治疗;观察组在奥美拉唑基础上联用碳酸镁铝治疗。比较两组患者用药效果和药物不良反应发生率。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);观察组治疗后症状评分低于对照组,差异有统计学意义(P<0.05);观察组症状改善时间及住院时间均低于对照组,幽门螺杆菌(Hp)根除率高于对照组,差异有统计学意义(P<0.05);观察组药物不良反应率略高于对照组,但差异无统计学意义(P>0.05);观察组复发率低于对照组,差异有统计学意义(P<0.05)。结论:碳酸镁铝联合奥美拉唑治疗胃溃疡合并胃出血的效果优于奥美拉唑单独用药,两种药物联用虽会增加不良反应的发生,但依旧在可控制范围内,提示联合用药方案可发挥药物协同作用,临床价值更加确切。

Objective:To explore the clinical effect and safety of magnesium aluminum carbonate and omeprazole in the treatment of gastric ulcer and gastric bleeding.Methods:From November 2018 to January 2020,75 patients with gastric ulcer and gastric hemorrhage were selected,they were divided into the two groups by digital double-blind method.The control group was treated with omeprazole alone.The observation group was treated with magnesium aluminum carbonate on the basis of omeprazole.The effect of medication and the incidence of adverse drug reactions were compared between the two groups of patients.Results:The total effective rate of treatment in the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).The symptom score of the observation group after treatment was lower than that of the control group,the difference was statistically significant(P<0.05).The symptom improvement time and hospitalization time of the observation group were lower than those of the control group,and the Hp eradication rate was higher than that of the control group,the difference was statistically significant(P<0.05).The adverse drug reaction rate of the observation group was slightly higher than that of the control group,but the difference was not statistically significant(P>0.05).The recurrence rate of the observation group was lower than that of the control group,the difference was statistically significant(P<0.05).Conclusion:The effect of magnesium aluminum carbonate combined with omeprazole in the treatment of gastric ulcer combined with gastric bleeding is better than omeprazole alone.Although the combination of the two drugs will increase the occurrence of adverse reactions,it is still within the controllable range,suggesting the combination medication regimen can play a synergistic effect of drugs,and the clinical value is more accurate.