具有生物活性的有机硅化合物的研究(Ⅷ)——1-烷酰氧基杂氮硅三环的合成及抗癌活性的研究

Studies on Organosilicon Compounds with Biological Activity(Ⅷ)——Synthesis of 1-Alkylsilatranes and Study of Antitumour

报道了用1-溴代Silatrane合成1-烷酰氧基-2,8,9-三氧-5-氮-1-硅杂三环[3,3,3,0.^(1.5)]十一碳烷的新方法。讨论了反应条件对该类化合物合成的影响,用各种方法确证了产物的结构,对某些化合物进行了抗癌活性实验。

l-Alkylacyloxy-2,8,9-trioxa-5-aza-l-silatricyclo[3,3, 3, 01,5] undecanes (1-alkylacyloxysilatranes) were synthesized by the reaction of 1-brornosilatrane with organic acids. Compare with the method using 1-ethoxysilatrane reagent, this reaction gave higher yields and simpler process of treatment. The influence of reaction conditions was discussed. The 1H NMR and 1R of the title compounds were determined.The antitumour activity of some acyloxysilatranes was studied, one of them had good curative effects on Ehrlich cancer.