某些芳环醛肟的烷基化反应

Alkylation of Some Aromatic Aldoximes

近年来分子内1,3-偶极环加成反应引起了较大的注意,它被用来合成某些杂环、多环以及结构复杂的天然产物,为了解决中间体问题,我们摸索了某些芳环醛肟(N-4-戊烯基)氮酮Nitrone的合成方法.通常,醛肟与活泼的卤代烃作用得到N-烷基化产物和O-烷基肟.

Alkylation of Z and E aromatic aldoximes are regioselective. Z aldoximes form mainly N-alkylated products, while E aldoximes form mainly O-alkylated ones. The reaction provides a convenient synthetic route for N-allkyl 1,3-dipolar nitrones and O-alkyl aldoximes.