手征性杂氮硅三环的合成

Preparation of Optically Active Silatranes

杂氮硅三环(Ⅰ)(Silatranes)是一类具有五配位键的环状有机硅醚类化合物。与通常的有机硅化合物不同,由于其分子内存在着氮硅原子间配位键而使这类化合物具有很高的生活理性,如毒性、抗癌活性、对动植物的刺激生长活性等,从而引起人们的广泛注意与研究。

Twelve pairs of optically active silatranes ( Ⅱ ) were prepared by cyclization of alkyltrielhoxysilane with D or L N,N-dihydroxyethyl-2-amino-butanol- 1 in the presence of alkaline hydroxide as catalyst.R=H;CH_(3);CH_(2)C_(1);CH_(2)CH_(2)O;CH_(2)=CH;C6H_(5);C6H6CH_(2);p-ClC6H_(4);m-ClC6H_(4);o-ClC6H_(4);p-CH_(3)C6H_(4);o-CH_(3)C6H_(4).Some of their physical constants and spectroscopic data are given.