摘要
2′-O-对甲苯磺酰基-c-AMP以对甲苯磺酰氯或三苯基膦/四氯化碳作缩合剂,与不同醇或胺反座得到3′,5′-环核苷酸磷酸酯或磷酰胺,以上他合物在乙二醇二甲醚中于-60°用茶化钠或蒽化钠反应可以脱去对甲苯磺酰基,同时分离了这些磷酸酯或磷酰胺的立体异构体。
By using tosyl chloride or triphenyl phosphine/carbon tetrachloride as condensing reagents,2’-tosyl c-AMP reacted with ROH or RNH_(2)to give nucleoside 3’,5’-cyclic phosphotri-esters and phosphoramidates in 30-60%yield.Detosylation was carried out by using sodium naphthaline at-60℃+in DME in 70-90%yield.The stereoisomers of these compounds have been separated and the structures have been identified by 1H NMR,^(13)C NMR,^(31)P NMR and FDMS.
作者
张礼和
马灵台
徐成
董令娇
王奇
王序
Zhang Lihe;Ma Lintai;Xu Chen;Dong Lingjiao;Wang Qi;Wang Xu(Department of Pharmaceutical Sciences,Beijing Medical College,Beijing)
出处
《高等学校化学学报》
SCIE
EI
CAS
1985年第10期903-909,共7页
Chemical Journal of Chinese Universities