保存突变蛋白质间氨基酸取代规律性的研究(Ⅰ)——不同种属来源胰岛素的构象分析

STUDIES ON REGULARITY OF AMINO ACIDS REPLACEMENT IN HOMOLOGOUS PROTEINS (Ⅰ)——CQNFQRMATIONAL ANALYSIS OF INSULINS FROM DIFFERENT SPECIES

本文研究了同源胰岛素间氨基酸取代的规律性。发现,保存突变不是随机进行的:在刚性结构上,取代氨基酸之间具有十分一致的构象参数;在螺旋的不同侧面上,氨基酸取代的频率是有很大差异的。

In this article the regularity of amino acid replacement among ho-mologues insulins was explored. It is shown that the reservational mutants are developed along no-random way: in the rigit structures of protein, replaced amino acids possess similar conformational parameters;a(?)varied side of α-helix frequency of replacement of amino acids is different from each other.