小儿非肝炎病毒性肝损害的临床特点及治疗分析

Clinical features and treatment of non-hepatitis viral liver damage in children

目的探讨小儿非肝炎病毒性肝损害的临床特点及治疗方法。方法选取2017年12月至2020年12月梅州市第二中医医院儿科收治的210例非肝炎病毒性肝损害儿童的临床资料,通过回顾性分析得出该病的临床特点,总结治疗方法和疗效。结果引起患儿非肝炎病毒性肝损害的常见原发病是呼吸道感染(83例,39.52%)、腹泻病(51例,24.29%)和传染性单核细胞增多症(32例,15.24%);患儿的主要临床症状为发热(130例,61.90%)、纳差(98例,46.67%)、腹痛腹泻(67例,31.90%);患儿主要体征为扁桃体肿大(78例,37.14%)、淋巴结肿大(68例,32.38%)、皮疹(53例,25.24%)。患儿的丙氨酸氨基转移酶(ALT)和天门冬氨酸氨基转移酶(AST)的异常发生率从治疗前的94.29%和88.57%降至9.05%和7.14%;患儿的ALT和AST水平从治疗前的(345.68±35.77)IU/L和(285.68±36.92)IU/L降至治疗后的(146.28±25.36)IU/L和(94.18±11.21)IU/L,差异有统计学意义(P<0.05)。结论儿童非肝炎病毒性肝损害的临床症状常常被忽视,需要引起医护人员和家长的重视,对于这类患儿需同时进行降酶护肝和原发病治疗。

Objective To investigate the clinical characteristics and treatment of non-hepatitis viral liver damage in children.Methods The clinical data of 210 children with non-hepatitis viral liver damage admitted to Meizhou Second Hospital of Traditional Chinese Medicine from December 2017 to December 2020 were selected.The clinical characteristics,treatment plan and efficacy of the disease were obtained through retrospective analysis.Results The common primary diseases that caused non-hepatitis viral liver damage in children were respiratory infection(83 cases,39.52%),diarrhea(51 cases,24.29%)and infectious mononucleosis(32 cases,15.24%);The main clinical symptoms were fever(130 cases,61.90%),anorexia(98 cases,46.67%),abdominal pain and diarrhea(67 cases,31.90%);the main signs were tonsil enlargement(78 cases,37.14%),lymphadenopathy(68 cases,32.38%),skin rash(53 cases,25.24%).The abnormal incidence of ALT and AST in children decreased from 94.29%and 88.57%before treatment to 9.05%and 7.14%;the levels of ALT and AST in children decreased from(345.68±35.77)IU/L and(285.68±36.92)IU/L before treatment decreased to(146.28±25.36)IU/L and(94.18±11.21)IU/L after treatment,and there were significant differences(P<0.05).Conclusions The clinical symptoms of non-hepatitis viral liver damage in children are often neglected,and need to be paid attention to by medical staff and parents.For these children,enzyme-reducing and liver protection and treatment of the original disease should be performed at the same time to restore the liver health of the children.