芳基丙酮酸的合成

Synthesis of Arylpyruvic Acids

本文报道用Meerwein芳基化反应由2-取代丙烯酸合成芳基丙酮酸的方法。 芳基重氮盐与2-乙酰氨基丙烯酸在丙酮-水溶液中、氯化铜存在下反应,迅速放出氮气,但从反应混合物中只分离到芳基丙酮酸1~9,产率中等。

Arylpyruvic acids were prepared in good yields by the reaction of aryldiazonium salts with 2-substituted acrylic acids, CH2 = CCO2H(Z =NHCOCH3,NHCHO, OCH3, or PO(OCH3)2), in the presence of cupric chloride.