羟甲基取代香豆素化合物的质谱

The Mass Spectra of Hydroxymethyl Substituted Coumarin Compounds

羟甲基取代香豆素化合物是亮菌甲素的同类物,由于亮菌甲素治疗胆道感染有较好的效果,而引起医学和化学界的重视,对从天然产物中提取和分离亮菌甲素及香豆素衍生物的合成进行了很多研究工作,关于香豆素及其衍生物的质谱亦有报道。

The hydroxymethyl substituted coumarin comounds are the homonuclear compounds of Armillarisin A.Since Armillarisin Ahas a cure effect on acute bile duct cholangitis,it is of value to medicine and chemistry area.Now,not only the Armillarisin Ahas been synthesized,but also a great deal of research work attemptting to improve the cure effect by changing substituted group of the compounds has been done.We worked for finding mass spectral fragmentation rule of these compounds,which were synthesized by Department of Chemistry of Nanjing University.The results are shown in the table.The mechanism of the fragmentation of hydroxy-metyl substituted coumarin is discussed in the paper too.