摘要
用硼酸三甲酯作反应试剂,以反应质谱法研究某些直链邻二醇类化合物的构型。实验结果表明:凡苏式构型的样品与硼酸三甲酯反应产生的特征离子丰度比均大于赤式构型的样品与其反应所产生的特征离子丰度比。由此可方便地利用反应质谱法来鉴别该类化合物的苏、赤式构型。
There are a lot of studies on the stereochemistry of cyclic glycols by means of mass spectrometry,but the studies on the relative configurations of acyclic glycols by MS have not been found in literatures.This paper presents that the relative configurations of some acyclic glycols were firstly determined by Reaction Mass Spectrometry(RMS)using trimethyl borate as reagent.In five pairs of three-and erythro-isomers studied,there are no characteristic differences between their routine chemical ionization mass spectra.But in their reaction mass spectra,the relative abundance ratio,r,of characteristic ion,[Ms+Mn+H-2CH_(3)OH]+,to reference ion,[Ms+H-H_(3)O]+,produced by the glycols of threo-configuration was much greater than that produced by erythro-isomers.Based upon this fact,we can distinguish the relative configurations between a pair of stereoisomeric acyclic glycols.And these phenomena were explained in virtue of the principles of stereochemistry.
作者
华苏明
李宏
陈耀祖
李海泉
翟建军
陈能煜
Hua Suming;Li Hong;Chen Yaozu;Li Haiquan;Zai Jianjun;Chen Nengyu(Department of Chemistry,Lanzhou University,Lanzhou;The Analytical and Testing Centre of Lanzhou University,Lanzhou)
出处
《高等学校化学学报》
SCIE
EI
CAS
1988年第11期1126-1130,共5页
Chemical Journal of Chinese Universities
关键词
反应质谱法
天然产物
苏式构型
赤式构型
Reaction mass spectrometry(RMS)
Natural products
Threo-and erythro-isomers configurations