摘要
本文报道了14种对氨基水杨酸稀土配合物的合成,通过元素分析、红外光谱、紫外光谱、摩尔电导、差热分析、X射线粉末衍射等手段对配合物进行了性质测定,确定了该系列化合物的组成为RE(PAS)_(3)nH_(2)O(RE=La,Ce,Pr,Nd,Sm,Eu,Tb,Dy,Ho,Er,Tm,Yb,Lu,Y,PAS为对氨基水杨酸根,n=1~3)。红外光谱证明稀土元素与配体中的羧基和其邻部位的羟基形成稳定的六元螯合环。抗结核菌及抑菌毒性实验表明,稀土配合物的毒性比对氨基水杨酸钠的毒性小;抗结核菌的作用比对氨基水杨酸钠的作用略强。
Fourteen new rare earth para-aminosalicylates were synthesized and characterized by elemenial analysis, IR, UV, Molar conductance, TG-DTA, and X-ray powder diffraction, Their chemical formulae were proved to be RE(PAS)_(3)nH_(2)O where RE are earth elements except Sc, Pm, Gd, PAS. para-aminosalicylate, n=1-3. The infrared spectra showed that rare earth elements are chelated by carboxyl group and hydroxyl group. Antituberculin and toxicity research showed rare earth para-aminosalicylates are less toxicity and alittle more efficient than sodium para-aminosalicylate in the inhibition of tuberculin.
作者
陈淑英
张新怀
王金玉
余光明
姜元
张训凯
Chen Shuying;Zhang Xinhua;Wang Jingyu;Yu Cuangming;Jiang Yuan;Zhang Xunkai(Vepartment of Chemistry,Lanzhou University,Lanzhou)
出处
《高等学校化学学报》
SCIE
EI
CAS
1988年第8期759-763,共5页
Chemical Journal of Chinese Universities
关键词
稀土配合物
对氨基水杨酸
合成
性质
Rare earth coordiation compound
Para-amino-salicylates
Synthesis
Charaeter