黄酮类化合物研究(Ⅷ)——7-取代黄酮及2’,4-二羟基-3-甲氧基-4’-取代查尔酮的合成

Studies on Flavonoids(Ⅷ)——Synthesis of 7-Substituted Flavones and 2’,4-Dihydroxy-3- methoxy-4’ -Substituted Chalcones

3,4′,7-三羟基黄酮和3,3′,4′,7-四羟基黄酮是中草药舒冠通糖浆的主要成份,该药对冠心病、心绞痛、胸闷有一定疗效。为系统研究黄酮类化合物的构效关系,我们在前文基础上又合成了5个新的4′-羟基-7-取代黄酮及5个3′-甲氧基-4′-羟基-7-取代黄酮。

The new 7-substituted flavones and four new 2’, 4-dihydroxy-3-metho-xy-4’-substituted chalcones were synthesized. The structures of these products were, proved by ^(1)H NMR, high resolution MS and elemental analysis.