不对称诱导(Ⅰ)--手性铵盐催化下芳醛与氯仿的加成反应

Asymmetric Induction(Ⅰ)Addition of Chloroform to Benzaldehyde in the Presence of Chiral Ammonium Salts

本文报导了在十种手性铵盐催化下芳醛和氯仿的不对称诱导反应。同时还对影响产物旋光纯度的因素及其诱导机理进行了讨论。

The chiral ammonium salts have been used as phase transfer catalysts for asymmetric synthesis.The addition of chloroform to benzaldehyde in the presence of chiral ammonium salts,quinine,N-benzyl-quininium chloride(BQC),N-benzyl-dihydroquininium(BDHQC),N-(o-nitrobenzyl)quininium chloride(NBQC),N-benzylquinidinium chloride(BQDC),N-benzylcinchonium chloride(BCDC),N-dodecylquininium bromide(DQB),quinine-acrylonitride copolymer(QN-AN),N-benzyl quininium chloride-acrylonitride copolymer(QNBC-AN)and N-benzyl-N-methylephedrinium chloride(BMEC)is reported.The effects on the optical yields,such as(Ⅰ)the solvent effect(Ⅱ)the amount of catalysts(Ⅲ)the time of reaction and the Induction machanism are studied.