阿达木单抗对活动性类风湿关节炎患者血清炎症指标的影响

Effect of adalimumab on serum inflammatory indicators in patients with active rheumatoid arthritis

目的探讨阿达木单抗对活动性类风湿关节炎患者血清炎症指标的影响。方法抽取2020年1月至2020年11月郑州人民医院收治的活动性类风湿关节炎患者28例,给予阿达木单抗治疗,以病情活动度判定临床应答情况,并分析炎症指标值。结果 28例患者中临床应答17例(60.71%),未应答11例(39.29%)。治疗前,应答者血清红细胞沉降率(ESR)、C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、γ-干扰素(IFN-γ)、白细胞介素-6(IL-6)、白细胞介素-17(IL-17)值与未应答者比较,P>0.05。治疗后,应答者血清ESR、CRP、TNF-α、IFN-γ、IL-6、IL-17值低于治疗前(P<0.05),未应答者血清TNF-α值低于治疗前(P<0.05)。治疗后应答者血清ESR、CRP、TNF-α、IFN-γ、IL-6及IL-17值低于未应答者(t=-8.544、-15.524、-3.629、-3.314、15.338、-11.868,P<0.05)。结论阿达木单抗有助于降低活动性类风湿关节炎患者的血清相关炎症指标水平,且实现临床应答者相应指标降低幅度更大。

Objective To investigate the effect of adalimumab on serum inflammation indicators in patients with active rheumatoid arthritis.Methods A total of 28 patients with active rheumatoid arthritis admitted to Zhengzhou People’s Hospital from January 2020 to November 2020 were treated with adalimumab,the clinical response was determined based on disease activity,and the inflammation index values were analyzed.Results Of the 28 patients,there were 17 patients with well-response(60.71%)and 11 patients with non-responses(39.29%).Before treatment,the serum erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ),interleukin-6(IL-6)andinterleukin-17(IL-17)values of well-response were compared with those of non-responders,P>0.05.After treatment,the serum ESR,CRP,TNF-α,IFN-γ,IL-6,and IL-17 values of well-response were lower than those before treatment(P<0.05),and serum TNF-αvalues of non-responders were lower than that before treatment(P<0.05).After treatment,the serum ESR,CRP,TNF-α,IFN-γ,IL-6 and IL-17 values of well-response were lower than those of non-responders(t=-8.544,-15.524,-3.629,-3.314,15.338,-11.868,P<0.05).Conclusions Adalimumab helps to reduce ESR,CRP,TNF-α,IFN-γ,IL-6 and IL-17 levels in active RA patients and the reduction of the corresponding indicators is greater in well-responses.