谷胱甘肽联合特布他林、糖皮质激素治疗慢性阻塞性肺疾病急性加重期患者的效果及对肺功能的影响

Effect of glutathione combined with terbutaline and glucocorticoid on patients with chronic obstructive pulmonary disease in acute exacerbations and its influence on lung function

目的探讨谷胱甘肽联合特布他林、糖皮质激素治疗慢性阻塞性肺疾病急性加重期(AECOPD)患者的效果及对肺功能的影响。方法抽取郑州人民医院2019年1月至2020年12月收治的AECOPD患者96例,按随机数字表法分为观察组(48例)与对照组(48例),对照组采用特布他林、糖皮质激素治疗,观察组在对照组基础上采用谷胱甘肽治疗。比较两组疗效,治疗前后症状评分,肺功能包括用力肺活量(FVC)、最高呼气流速(PEF)、第一秒用力呼气容积(FEV1),血清炎性因子水平包括肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)和不良反应发生率。结果观察组总有效率为93.75%(45/48),高于较对照组的79.17%(38/48),P<0.05;治疗后,观察组气促、咳嗽、咳痰症状评分低于对照组(P<0.05);观察组FVC、PEF、FEV1高于对照组(P<0.05);观察组血清TNF-α、hs-CRP、IL-6水平低于对照组(P<0.05);观察组不良反应发生率为12.50%(6/48),对照组为10.42%(5/48),P>0.05。结论 AECOPD患者采用谷胱甘肽联合特布他林、糖皮质激素治疗可提高疗效,改善微炎症状态,缓解临床症状,提高肺功能,且具有用药安全性。

Objective To investigate the effect of glutathione combined with terbutaline and glucocorticoid on patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)and its effect on lung function.Methods A total of 96 patients with AECOPD in People’s Hospital of Zhengzhou from January 2019 to December 2020 were selected and divided into observation group(n=48)and control group(n=48)according to random number table method.The control group received terbutarin and glucocorticoid,and the experimental group received glutathione on the basis of the control group.The efficacy,symptom score,lung function including forced vital capacity(FVC),maximum expiratory flow rate(PEF),forced expiratory volume in the first second(FEV1),serum inflammatory factor levels including tumor necrosis factor-α(TNF-α),hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6)and incidence of adverse reactions were compared between the two groups before and after treatment.Results The total effective rate of the observation group was 93.75%(45/48),which was higher than 79.17%(38/48)of the control group(P<0.05).After treatment,the symptom scores of shortness of breath,cough and expectoration in observation group were lower than those in control group(P<0.05);FVC,PEF and FEV1 in observation group were higher than those in control group(P<0.05);the serum levels of TNF-α,hs-CRP and IL-6 in observation group were lower than those in control group(P<0.05).The incidence of adverse reactions in the observation group was 12.50%(6/48),which in the control group was 10.42%(5/48),P>0.05.Conclusions The combination of glutathione,terbutaline and glucocorticoid in the treatment of AECOPD can improve the curative effect,improve the micro inflammatory state,relieve the clinical symptoms,improve the lung function,and has drug safety.