miR-146a参与不同疾病的研究进展

Research Progress on miR-146a Involved in Different Diseases

miR-146a是近年来miRNA研究的热点,其在不同物种中高度保守,并参与了各种类型疾病的发生与发展,如炎症、自身免疫性疾病、癌症与肥胖症等,其机制主要通过TLR4、MyD88、NF-κB和Akt等信号通路来发挥作用。就miR-146a在不同疾病过程中的作用及其机制进行综述,为深入研究miR-146a在各类疾病中的调节作用提供资料。

miR-146 a is a hot topic in recent miRNA study and keeps highly conserved in different species.It is involved in the occurrence and development of various types of diseases,such as inflammation,autoimmune diseases,cancer and obesity,and its mechanism mainly plays a role through TLR4,MyD88,NF-κB and Akt signaling pathways.In this paper,the roles and mechanisms of miR-146 a in different disease processes are reviewed to provide information for further research on the regulatory role of miR-146 a in various diseases.