FePS_(3)纳米片制备及其体外光热-光动力学联合治疗性能研究

FePS_(3) Nanosheets:Preparation and Potential in Photothermal-photodynamic Therapy

光学治疗作为一种肿瘤治疗策略具有微创、毒副作用小、治疗效率高等优势而得到广泛研究,但单一光学治疗并不能完全消除肿瘤。新兴的二维纳米材料在光学治疗领域的优势引起了广泛关注。本研究探索了金属磷三硫族元素化合物FePS_(3)纳米片的制备及其多功能光学治疗性能。采用高温固相法合成FePS_(3)块体并通过超声协助的液相剥离法得到FePS_(3)纳米片,该纳米片的平均水合粒径小于200 nm(平均153 nm),对1064 nm激光的光热转换效率为19.7%,且能在660 nm激光辐照下产生活性氧。细胞实验结果表明,FePS_(3)纳米片具有良好的光热治疗和光动力学治疗效果。因此,FePS_(3)纳米片可同时作为光热剂和光敏剂获得光热-光动力学联合治疗肿瘤功能,肿瘤治疗应用潜力较大。

Phototherapy,a tumor therapeutic modality,has been widely studied due to its advantages of minimal invasiveness,low side effect,and high therapeutic efficacy.However,single phototherapy cannot achieve complete tumor elimination.Recently,the emerging two-dimensional nanomaterials have attracted great attention in the field of phototherapy.Here,FePS_(3)nanosheets were prepared,and then its phototherapeutic properties were investigated.The bulk FePS_(3)was synthesized by a high-temperature solid-phase method and FePS_(3)nanosheets were obtained by an ultrasonic-assisted liquid phase exfoliating method.The nanosheets displayed particle morphology with average hydrated size of less than 200 nm(153 nm in average),performed photothermal conversion efficiency of 19.7%under 1064 nm laser irradiation,and generated reactive oxygen species under 660 nm laser irradiation.Cell experiment results showed that FePS_(3)nanosheets had excellent photothermal and photodynamic therapeutic effects.Therefore,FePS_(3)nanosheets can be used as both photothermal agent and photosensitizer to achieve combined photothermal-photodynamic therapy for treating tumors,which shows great application potential.