Mex-3 RNA结合蛋白在肿瘤中的研究进展

Research progress of Mex-3 RNA-binding proteins in tumor

Mex-3蛋白是包含KH结构域的RNA结合蛋白家族成员之一。哺乳动物Mex-3蛋白家族包含4个成员,分别为Mex-3A,Mex-3B,Mex-3C和Mex-3D,它们都含有两个RNA结合的KH结构域和一个位于C端的具有E3泛素连接酶活性的环指(RING)结构域。研究表明,Mex-3蛋白在RNA代谢、信号转导、能量代谢、胚胎发育和免疫应答等方面均起到重要的作用。此外,Mex-3蛋白还被发现与肿瘤的进程和治疗密切相关,有望成为肿瘤治疗的新靶点。本文介绍了Mex-3家族蛋白的结构和定位,重点综述了其与肿瘤相关的研究进展,以期为癌症治疗研究提供新的启示。

Mex-3 protein is a member of RNA binding protein family which containing KH domain.The mammalian Mex-3 protein family consists of four members,Mex-3A,Mex-3B,Mex-3C and Mex-3D,which contains two KH RNA-binding domains and a RING-finger domain with E3 ubiquitin ligase activity at C-terminal.Studies have shown that Mex-3 proteins played an important role in RNA metabolism,signal transduction,energy metabolism,embryonic development and immune response.In addition,Mex-3 proteins have been found to be closely related to tumor progression and tumor treatment,and are expected to be new targets for tumor treatment.This paper introduced the structures and localization of Mex-3 proteins,and focused on the research progresses related to tumors,aiming at provide new enlightenment for cancer treatment research.