中医证型与BRAF基因型在甲状腺乳头状癌中的分布相关性分析

Distribution of TCM Syndromes and BRAF Genotype in Papillary Thyroid Carcinoma

目的:对甲状腺乳头状癌(PTC)术前患者的中医证型进行调查,同时对手术切除肿瘤组织进行BRAF基因检测,了解中医证型与BRAF基因型在PTC中的分布规律。方法:选取东莞市人民医院甲状腺专科2019年1月至2019年12月期间收治的210例行甲状腺癌根治术并经术后病理确诊的PTC患者。结合文献研究和中医理论,对210例PTC患者进行中医辨证,同时进行BRAF基因检测。结果:210例甲状腺癌患者中痰浊证68例(32.4%)、火热证53例(25.2%)、气滞证31例(14.8%)、阴虚证33例(15.7%)、血瘀证25例(11.9%);BRAF基因分型突变型132例(62.9%),野生型78例(37.1%)。在痰浊证型中,BRAF突变率达80.9%,高于其他证型,差异具有统计学意义(P<0.05)。结论:结合中医证型与BRAF基因型在PTC中的分布规律对临床整体辨证施治具有指导意义。

Objective To investigate the distribution and relationship of the TCM Syndromes and BRAF genotype in thyroid papillary carcinoma.Methods Combined with literature research and TCM theory,TCM syndrome study and BRAF gene detection were performed on 210 patients with papillary thyroid carcinoma.Results Among 210 patients,68 cases of phlegm turbidity(32.4%),53 cases of fever(25.2%),31 cases of Qi stagnation(14.8%),33 cases of yin deficiency(15.7%),25 cases of blood stasis(11.9%),132 cases of BRAF genotyping mutation(62.9%)and 78 cases of wild type(37.1%).In the phlegm turbid syndrome type,the BRAF mutation rate was 80.9%,which was significantly higher than other syndrome types(P<0.05).Conclusion Combining the distribution of TCM syndrome type and BRAF genotype in papillary thyroid carcinoma would guide the diagnosis and treatment.