金麦温胆汤对2型糖尿病患者的降糖疗效及肠道菌群的影响

Effect of Jinmai Wendan Decoction on Hypoglycemic Effect and Intestinal Flora of Type 2 Diabetes Patients

目的:研究金麦温胆汤治疗2型糖尿病(T2DM)患者的临床疗效。方法:选取厦门大学附属福州第二医院2018年11月至2020年12月期间收治的62例T2DM患者,根据治疗方案不同分为观察组和对照组,各31例。对照组采用常规西医治疗,观察组在对照组基础上加用金麦温胆汤。比较两组临床疗效及肠道菌群数目。结果:观察组患者治疗总有效率为93.55%,高于对照组的70.97%,差异具有统计学意义(P<0.05);治疗前两组患者的空腹血糖(FPG)、餐后2 h血糖(2h PG)、糖化血红蛋白(HbA1c)比较,差异无统计学意义(P>0.05);治疗后观察组的FPG、2h PG、HbA1c均低于对照组,差异具有统计学意义(P<0.05)。治疗前,两组患者的厚壁杆菌、肠球菌、双歧杆菌数目比较,差异无统计学意义(P>0.05);治疗后观察组厚壁杆菌、肠球菌数目均低于对照组,双歧杆菌数目高于对照组,差异具有统计学意义(P<0.05)。治疗前,两组患者的C反应蛋白(CRP)、肿瘤坏死因子–α(TNF–α)比较,差异无统计学意义(P>0.05);治疗后观察组CRP、TNF–α均低于对照组,差异具有统计学意义(P<0.05)。结论:金麦温胆汤治疗T2DM患者临床疗效确切,可有效降低血糖,改善肠道菌群,减轻机体炎症反应。

Objective To study the clinical efficacy of Jinmai Wendan Decoction in the treatment of type 2 diabetes mellitus(T2DM).Methods 62 T2DM patients admitted to Fuzhou Second Hospital affiliated to Xiamen University from November 2018 to December 2020 were selected and divided into observation group and control group according to different treatment plans,with 31 cases in each group.The control group was treated with conventional western medicine,and the observation group was treated with Jinmai Wendan Decoction on the basis of the control group.The clinical efficacy and intestinal flora of the two groups were compared.Results The total effective rate of observation group was 93.55%,which was higher than that of control group(70.97%),the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in fasting blood glucose(FPG),2h postprandial blood glucose(2h PG)and glycosylated hemoglobin(HbA1c)between 2 groups(P>0.05).After treatment,FPG,2h PG and HbA1c in the observation group were lower than those in the control group,with statistical significance(P<0.05).Before treatment,there was no significant difference in the number of firmicutes,enterococcus and bifidobacteria between 2 groups(P>0.05).After treatment,the number of firmiculosis and enterococcus in the observation group was lower than that in the control group,and the number of bifidobacteria was higher than that in the control group,with statistical significance(P<0.05).Before treatment,there was no significant difference in C-reactive protein(CRP)and tumor necrosis factor(TNF--α)between 2 groups(P>0.05).After treatment,CRP and TNF--αin the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).Conclusion Jinmai Wendan Decoction is effective in treating T2DM patients.It can effectively reduce blood glucose,improve intestinal flora and reduce inflammation.