儿童幽门螺杆菌感染的现状、表现及治疗进展

Research progress on current situation,clinical manifestations,and treatment of Helicobacter pylori infection in children

幽门螺杆菌(Helicobacter pylori,H.pylori)是世界上感染率最高的细菌之一,多于儿童时期感染,其定植在胃黏膜,是引起急慢性胃炎、消化性溃疡、胃癌等多种胃肠道疾病的重要因素。儿童H.pylori感染在流行病学、临床表现及根除治疗方面与成人有显著差别。本综述旨在讨论儿童与成人在流行病学、临床表现及根除治疗等方面的差异,为临床诊断及治疗儿童H.pylori感染提供思路。

Helicobacter pylori(H.pylori)is one of the bacteria with the highest infection rate in the world.H.pylori infection occurs often in childhood.H.pylori colonized in gastric mucosa is an important factor causing acute and chronic gastritis,peptic ulcer,gastric cancer,and other gastrointestinal diseases.There are significant differences in epidemiology,clinical manifestations,and eradication treatment between children and adults with H.pylori infection.The purpose of this review is to discuss the differences in epidemiology,clinical manifestations,and eradication therapy between children and adults,and to provide ideas for the clinical diagnosis and treatment of H.pylori infection in children.