类风湿关节炎实验性动物模型研究进展

Advances on experimental models of rheumatoid arthritis

类风湿关节炎(rheumatoid arthritis,RA)是一种病因不明的慢性自身免疫性疾病,不仅影响关节的活动和健康,还累及全身多个组织器官。RA目前尚无特效药治疗,是国内外研究的热点和难点,构建与人类RA相似度高的动物模型对研究该疾病的发病机制及药物治疗至关重要。该文就目前常用RA动物模型的构建方法、发病机制及病理特征等展开论述,以期为合理选择实验动物模型作为RA的基础研究与药物筛选提供依据和参考。

Rheumatoid arthritis(RA)is a chronic immune-mediated synovial disease with unknown aetiology;therefore,it is considered a chronic disease that cannot be cured.RA is caused by a complex interaction between genetic and environmental factors.As such long-standing efforts have been made for better understanding of disease pathogenesis and the development of new classes of therapeutics,the continuing elucidation of pathogenic events underlying RA mostly relies on animal model studies.Individually animal models allow molecular and spatiotemporal dissection of various pathological processes of RA development.We have herein comprehensively discussed different animal models in induction methods,pathogenesis,pathological events and disease characteristics,hoping to provide the basis and reference for the rational selection of experimental animal models for the basic research and drug screening of RA.