摘要
类风湿关节炎(rheumatoid arthritis,RA)是一种病因不明的慢性自身免疫性疾病,不仅影响关节的活动和健康,还累及全身多个组织器官。RA目前尚无特效药治疗,是国内外研究的热点和难点,构建与人类RA相似度高的动物模型对研究该疾病的发病机制及药物治疗至关重要。该文就目前常用RA动物模型的构建方法、发病机制及病理特征等展开论述,以期为合理选择实验动物模型作为RA的基础研究与药物筛选提供依据和参考。
Rheumatoid arthritis(RA)is a chronic immune-mediated synovial disease with unknown aetiology;therefore,it is considered a chronic disease that cannot be cured.RA is caused by a complex interaction between genetic and environmental factors.As such long-standing efforts have been made for better understanding of disease pathogenesis and the development of new classes of therapeutics,the continuing elucidation of pathogenic events underlying RA mostly relies on animal model studies.Individually animal models allow molecular and spatiotemporal dissection of various pathological processes of RA development.We have herein comprehensively discussed different animal models in induction methods,pathogenesis,pathological events and disease characteristics,hoping to provide the basis and reference for the rational selection of experimental animal models for the basic research and drug screening of RA.
作者
李利青
张逢
彭馥芝
罗前颖
李鑫
刘良
LI Li-qing;ZHANG Feng;PENG Fu-zhi;LUO Qian-ying;LI Xin;LIU Liang(Guangxi Provincial Key Laboratory of Preventive and Therapeutic Research in Prevalent Diseases in West Guangxi, Youjiang Medical University for Nationalities, Baise, Guangxi 533000, China;Institute of Innovation and Applied Research in Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, China;State Key Laboratory of Quality Research in Chinese Medicine, Macao University of Science and Technology, Macao 999078, China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2021年第11期1492-1497,共6页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No81803993)
湖南省科技创新重大项目(No2020SK1020)
湖南省“刘良院士专家工作站”资助项目(No湘科协通〔2020〕34号)
广西自然科学基金项目(No2019GXNSFBA245042,2020GXNSFAA297053)。