缺血性脑卒中与血管性痴呆在发病机制上的联系

Relationship of pathogenesis between ischemic stroke and vascular dementia

缺血性脑卒中造成的脑损伤可以继发认知或行为障碍。研究表明,缺血性脑卒中是血管性痴呆的一个危险因素。涉及共同的病理生理过程及相似的危险因素。在发病机制上存在联系,均包含了内皮细胞功能紊乱及血脑屏障通透性增高。缺血性脑卒中后存在的微梗死、微血管改变、局部神经元萎缩和神经退行性变均可能是继发血管性痴呆的病理机制。但是,两者相关的具体机制仍然未完全阐明。

Ischemic stroke could cause brain damage and subsequent cognitive or behavioral disorders.Studies have shown that ischemic stroke is a risk factor of vascular dementia,involving common pathophysiological processes and similar risk factors,which are related in pathogenesis,including endothelial dysfunction and the disrupted blood-brain barrier permeability.Micro infarct,microvascular changes,brain atrophy and neurodegenerative changes may be the pathological mechanism of secondary vascular dementia.However,the specific mechanism of the two is still not fully clarified,which will become the focus of future research.