DKK3、Wnt/β-连环蛋白信号通路与宫颈癌关系的研究进展

Research Progress on the Relationship between DKK3,Wnt/β-Catenin Signaling Pathway and Cervical Cancer

宫颈癌为女性恶性肿瘤之一,对于其发病机制及所涉及的通路分子的研究越来越深入。其中Wnt/β-连环蛋白(β-catenin)信号通路的研究受到高度关注。Wnt/β-catenin信号通路涉及广泛的生理和病理过程,包括细胞生长、分化、个体发育、迁移、遗传稳定性、凋亡、干细胞自我更新和维持成人组织稳态。稳定的β-catenin在细胞质中积累并转移到细胞核,激活Wnt/β-catenin信号通路,是多种癌症的诱发因素之一。β-catenin的积累在Wnt/β-catenin信号通路占据核心位置。β-catenin通过Wnt/β-catenin信号通路驱动靶基因,参与宫颈癌多步骤的发生及发展。而Dickkopf相关蛋白3(DKK3)可能通过降解β-catenin、阻断β-catenin的核转运,抑制Wnt/β-catenin信号通路,在抑制宫颈癌的发生、发展中发挥潜在作用。因此,深入研究DKK3、Wnt/β-catenin信号通路与宫颈癌的关系,显得尤为重要。

Cervical cancer is one of the malignant tumors in women,and the pathogenesis and related pathway molecules have been studied more and more deeply.Among them,the research on Wnt/β-catenin signaling pathway has attracted great attention.The Wnt/β-catenin signaling pathway involves a wide range of physiological and pathological processes,including cell growth,differentiation,ontogeny,migration,genetic stability,apoptosis,stem cell self-renewal,and maintenance of adult tissue homeostasis.Stableβ-catenin is accumulated in the cytoplasm and transferred to the nucleus,which activates the Wnt/β-catenin signaling pathway and is one of the inducing factors of multiple cancers.The accumulation ofβ-catenin occupies a core position in the Wnt/β-catenin signaling pathway.β-catenin drives target genes through Wnt/β-catenin signaling pathway and participates in the multi-step occurrence and development of cervical cancer.DKK3 may inhibit the Wnt/β-catenin signaling pathway by degradingβ-catenin,blocking the nuclear transport ofβ-catenin,and thus become a potential key role in the inhibition of cervical cancer.Therefore,it is particularly important to study the relationship between DKK3,Wnt/β-catenin signaling pathway and cervical cancer.