微小RNA在子宫内膜异位症中的研究进展

Research Progress of MicroRNA in Endometriosis

子宫内膜异位症(endometriosis,EMs)是一种育龄期女性常见的妇科疾病,其临床表现复杂多样,通常表现为疼痛、不孕和性交不适等症状。近年来EMs发病率呈明显上升趋势,给患病女性带来生理与心理痛苦的同时,也给社会带来了巨大的医疗和经济负担,但其发病机制尚未得到清晰阐述。目前大量研究表明一些具有重要功能的微小RNA(microRNA,miRNA)与EMs的发生关系密切。miRNA是一类长约22个碱基的内源性非编码RNA分子,可以在转录后调控靶基因,影响蛋白质表达,从而影响细胞活动。对miRNA调节异位子宫内膜细胞的功能,如细胞增殖、凋亡及细胞黏附转移、血管生成等方面的作用进行综述,以期为EMs的诊断、治疗和预后提供有效帮助。

Endometriosis(EMs)is a common gynecological disease in women of childbearing age.Its clinical manifestation is complicated,often characterized by pain,infertility,intercourse discomfort and other symptoms.In recent years,the incidence of EMs is on the rise,which brings physical and psychological burden to women,and also brings huge medical and economic burden to the society.But its pathogenesis has not been clearly explained.At present,a large number of studies have shown that some microRNAs(miRNAs)with important functions are closely related to the occurrence of EMs.MiRNAs are a class of endogenous non-coding RNA molecules with a length of about 22 bases,which can regulate target genes after transcription and affect protein expression,thus affecting cell activities.Therefore,a comprehensive explanation of the functions of miRNAs in regulating ectopic endometrial cells,such as cell proliferation,apoptosis,cell adhesion and metastasis,and angiogenesis,can provide effective help for the diagnosis,treatment and prognosis of EMs.