摘要
目的:探讨血小板及凝血指标对卵巢子宫内膜异位囊肿的诊断价值。方法:回顾性分析2013年5月—2017年5月因卵巢囊肿于天津中医药大学第二附属医院妇科行手术治疗的患者病例资料。术后经病理证实为卵巢子宫内膜异位囊肿的患者为观察组,单纯卵巢囊肿的患者为对照组,观察2组患者的血小板计数(PLT)、血小板压积(PCT)、平均血小板体积(MPV)、血小板分布宽度(PDW)、大型血小板计数(P-LCR)、凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血酶时间(APTT)、纤维蛋白原(FIB)、凝血酶原国际比值(INR)、血浆D-二聚体及血清糖类抗原125(CA125)的变化,评价血小板及凝血指标对卵巢子宫内膜异位囊肿的诊断价值。结果:术前观察组的PLT、PCT、CA125高于对照组,PDW、APTT低于对照组,差异均有统计学意义(P<0.05)。观察组Ⅲ、Ⅳ期的PLT、PCT、MPV高于Ⅰ、Ⅱ期,PDW、P-LCR、APTT低于Ⅰ、Ⅱ期,差异均有统计学意义(P<0.05)。术前观察组CA125与MPV呈正相关,与PDW、PLCR呈负相关。观察组术后PLT、PCT、MPV低于术前,PDW、P-LCR高于术前,差异均有统计学意义(P<0.05)。结论:血小板及凝血相关检测指标与卵巢子宫内膜异位囊肿发病有关,在临床上具有一定的诊断价值,但尚需进一步研究。
Objective:Discuss the value of platelet and coagulation parameters in diagnosis of ovarian endometriosis cysts.Methods:Patients with ovarian cyst treated by gynecologic surgery in the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine from May 2013 to May 2017 were selected.Patients with ovarian endometriosis cysts confirmed by pathology after surgery were the observation group,patients with simple cysts were the control group.The parameters of two groups were compared:platelet count(PLT),plateletcrit(PCT),mean platelet volume(MPV),platelet distribution width(PDW),large platelet count(P-LCR),prothrombin time(PT),thrombin time(TT),activated partial thrombin time(APTT),fibrinogen(FIB),prothrombin international ratio(INR),plasma D-dimer and serum CA125.To evaluate the diagnostic value of platelet and coagulation parameters in ovarian endometriosis cysts.Results:Compared with the control group,PLT,PCT,CA125 were higher and PDW,APTT were lower in the observation group,the difference was statistically significant(P<0.05).Compared with the observation groupⅠ,Ⅱ,PLT,PCT and MPV were higher and PDW、P-LCR、APTT were lower in the observation groupⅢ,Ⅳ,the difference was statistically significant(P<0.05).There was a positively correlated between CA125 and MPV,negative correlation between CA125 and PDW,P-LCR in the observation group.Compared with preoperative,postoperative PLT,PCT and MPV were lower,PDW,P-LCR were higher in observation group,the difference was statistically significant(P<0.05).Conclusions:The correlation between platelet and coagulation parameters and the incidence of ovarian endometriosis cysts has certain diagnostic value in clinic,but further study is needed.
作者
王雅楠
宋殿荣
张崴
WANG Ya-nan;SONG Dian-rong;ZHANG Wei(Department of Gynecology,Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300250,China)
出处
《国际妇产科学杂志》
CAS
2021年第5期597-600,共4页
Journal of International Obstetrics and Gynecology
基金
国家自然科学基金(81303094)。