联合疗法治疗Hp相关性胃溃疡的疗效分析

Analysis of the Clinical Efficacy of Combination Therapy in the Treatment of Helicobacter Pylori-related Gastric Ulcer

目的观察铝碳酸镁联合奥美拉唑治疗幽门螺旋杆菌相关性胃溃疡的临床疗效。方法以2020年1—6月在医院消化科治疗的76例幽门螺旋杆菌相关性胃溃疡患者作为研究对象,随机分为单用药组和联合用药组,其中单用药组采用奥美拉唑治疗,联合用药组在此基础上加用铝碳酸镁治疗。根据胃镜结果判断两组患者治疗后的疗效,对两组患者治疗前后临床症状进行评分,记录并比较其治疗前后的临床症状评分以及治疗后呕吐、恶心、眩晕、腹泻、口干等不良反应发生情况。结果治疗后联合用药组的治疗总有效率(97.37%)明显较单用药组治疗总有效率(78.95%)高,差异具有统计学意义(P<0.05);治疗后,两组患者评分均下降,其中联合用药组相对单用药组下降更加显著,差异有统计学意义(P<0.05);而两组患者治疗后的呕吐恶心等不良反应发生率相似,差异无统计学意义(P>0.05)。结论幽门螺旋杆菌相关性胃溃疡患者在奥美拉唑治疗基础上加用铝碳酸镁能提高治疗效果,改善临床症状。

Objective To observe the clinical efficacy of hydrotalcite combined with omeprazole in the treatment of helicobacter pylori-related gastric ulcer.Methods 76 cases of helicobacter pylori-related gastric ulcer patients treated in the gastroenterology department of our hospital from January to June 2020 were randomly divided into single drug group and combination drug group.The single drug group was treated with omeprazole treatment,the combination group was treated with hydrotalcite on this basis.According to the results of gastroscopy,the efficacy of the two groups of patients after treatment was judged,the clinical symptoms of the two groups of patients before and after treatment were scored,and the clinical symptoms scores before and after treatment were recorded and compared,as well as the occurrence of adverse reactions such as vomiting,nausea,dizziness,diarrhea,and dry mouth after treatment.Results After treatment,the effective rate(97.37%)of the combined drug group was significantly higher than that of the single drug group(78.95%),and the difference was statistically significant(P<0.05);after treatment,the scores of the two groups of patients decreased.Among them,the combined medication group decreased more significantly than the single medication group,and the difference was statistically significant(P<0.05);while the incidence of adverse reactions such as vomiting and nausea after treatment in the two groups was similar,the difference was not statistically significant(P>0.05).Conclusion The addition of hydrotalcite to patients with helicobacter pylori-related gastric ulcer on the basis of omeprazole treatment can improve the therapeutic effect and improve the clinical symptoms.