摘要
Dear Editor,Sperm cooperation has been observed in multiple species(Pizzari and Foster,2008),yet its existenee and benefit for reproductive success in mammals remains underexplored.Here,combining tissue-clearing with deep three-dimensional(3D)imagi ng,we dem on strate that postcopulatory mouse sperm congregate into unidirectional sperm cooperative clusters at the utero-tubal junction(UTJ),a key physical barrier for passage into the oviduct.
基金
This work was supported by the National Key Research and Development Program of China(2018YFC1004500 to YZ,2019YFA0802600 to YZ,2016YFA0500903 to ED,2017YFC1001401 to ED,2015CB943003 to YZ)
the Strategic Priority Research Program of the CAS(XDA16020700 to HW)National Basic Research Program of China(81490742 to ED)
National Natural Science Foundation of China(81490741 to HW,31671201 to YZ,31671568 to ED)
Youth Inn ovation Promotion Association,CAS(Grant No.2016081 to YZ)
The Eunice Kennedy Shriver Nation al Institute of Child Health and Human Development(grants HD088412 and P01HD087157)supports our studies of UTJ migration defects in mouse models.
